Additional file 4 of Optical mapping of human embryonic stem cell-derived cardiomyocyte graft electrical activity in injured hearts
Bibliographic record
Abstract
Additional file 4: Supplementary Fig. S4. Simultaneous di-2-ANEPEQ imaging and direct electrode recording of hESC-CM graft electrical activity. A cryoinjured heart with hESC-CM graft (H7 line) was impaled with a sharp electrode within the graft tissue to correlate the di-2-ANEPEQ-derived voltage signal with direct intracellular voltage recordings. A: Epicardial still image taken on the di-2-ANEPEQ channel, showing the uncoupled hESC-CM graft footprint (yellow dotted line) inside the cryoinjury region (white dotted line) and the recording electrode positioned in graft tissue. Two ROIs are indicated: one in host myocardium outside the cryoinjury zone and one in hESC-CM graft tissue overlying the tip of the recording electrode. B: Simultaneously acquired oAPs for these two ROIs, as well as the simultaneously acquired direct voltage and ECG recordings. Note the excellent temporal correlation between the direct electrode recordings and di-2-ANEPEQ-derived oAPs from this hESC-CM graft, which was uncoupled from the host.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.024 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.003 | 0.002 |
| Open science | 0.003 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.906 | 0.275 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".