AlzheimerNet: An Effective Deep Learning Based Proposition for Alzheimer's Disease Stages Classification From Functional Brain Changes in Magnetic Resonance Images
Bibliographic record
Abstract
Alzheimer's disease is largely the underlying cause of dementia due to its progressive neurodegenerative nature among the elderly. The disease can be divided into five stages: Subjective Memory Concern (SMC), Mild Cognitive Impairment (MCI), Early MCI (EMCI), Late MCI (LMCI), and Alzheimer's Disease (AD). Alzheimer's disease is conventionally diagnosed using an MRI scan of the brain. In this research, we propose a fine-tuned convolutional neural network (CNN) classifier called AlzheimerNet, which can identify all five stages of Alzheimer's disease and the Normal Control (NC) class. The ADNI database's MRI scan dataset is obtained for use in training and testing the proposed model. To prepare the raw data for analysis, we applied the CLAHE image enhancement method. Data augmentation was used to remedy the unbalanced nature of the dataset and the resultant dataset consisted of 60000 image data on the 6 classes. Initially, five existing models including VGG16, MobileNetV2, AlexNet, ResNet50 and InceptionV3 were trained and tested to achieve test accuracies of 78.84%, 86.85%, 78.87%, 80.98% and 96.31% respectively. Since InceptionV3 provides the highest accuracy, this model is later modified to design the AlzheimerNet using RMSprop optimizer and learning rate 0.00001 to achieve the highest test accuracy of 98.67%. The five pre-trained models and the proposed fine-tuned model were compared in terms of various performance matrices to demonstrate whether the AlzheimerNet model is in fact performing better in classifying and detecting the six classes. An ablation study shows the hyperparameters used in the experiment. The suggested model outperforms the traditional methods for classifying Alzheimer's disease stages from brain MRI, as measured by a two-tailed Wilcoxon signed-rank test, with a significance of < 0.05.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".