Additional file 4 of An in vitro bioengineered model of the human arterial neurovascular unit to study neurodegenerative diseases
Bibliographic record
Abstract
Additional file 4: Supplemental Figure 4. Aβ and p-tau histology. Cryopreserved bioengineered arterial NVU were cut longitudinally to show a cross-section of the NVU wall. a) Immunohistochemistry against OC fibril confirmed the deposition of Aβ fibril both in the neuron layer (β-tub III positive, white arrow) as well as deeper in the vascular wall (blue arrows). b) The expression of Aβ was further investigated by staining against Aβ 1–16. Positive signal was found both deep in the vascular wall (white arrow) as well as co-localized within MAP 2 positive cells (yellow arrow). c) Immunohistochemistry against AT8 suggest the deposition of p-tau both within neuron (MAP 2 positive, yellow arrow) as well as extracellular (white arrow), purple arrow shows the remaining of the scaffold. Human brains were used as representative staining pattern. ABL = albumen.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.017 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.881 | 0.202 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".