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Additional file 1 of Sex differences in mitochondrial gene expression during viral myocarditis

2024· article· en· W6902048590 on OpenAlexaff

Bibliographic record

VenueFigshare · 2024
Typearticle
Languageen
FieldMedicine
TopicViral Infections and Immunology Research
Canadian institutionsCentre hospitalier universitaire de Québec
Fundersnot available
KeywordsTranscriptomeMitochondrial DNATable (database)Mitochondrial diseaseViral MyocarditisMyocarditis

Abstract

fetched live from OpenAlex

Supplementary Material 1: Additional File 1: Figure S1. Other pathways/genesets from F-MYO vs M-MYO Enrichment Mapping. Figure S2. Row normalized heatmaps from GSEA analysis comparing mitochondrial pathways for F-MYO vs M-MYO. Figure S3. Enrichment mapping results from Metascape for F-CON comparing F-CON vs F-MYO. Figure S4. Enrichment mapping results from Metascape for F-MYO comparing F-CON vs F-MYO. NMD = nonsense mediated decay, EJC = exon junction complex. Figure S5. Enrichment mapping results from Metascape for M-CON comparing M-CON vs M-MYO. Figure S6. Enrichment mapping results from Metascape for M-MYO comparing M-CON vs M-MYO. Figure S7. Verification of mitochondrial fraction purity. Figure S8. Background respiration in the presence of antimycin A measured by Clark electrode. Figure S9. Females with myocarditis express higher levels of mitochondrial master regulators PGC1α and NRF1. Table S1. gProfiler enrichment results comparing males and females with myocarditis Table S2. Published sex differences in cardiac mitochondrial properties

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.012
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.829
Threshold uncertainty score0.244

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.012
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.003
Science and technology studies0.0010.000
Scholarly communication0.0010.001
Open science0.0020.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.8290.172

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.032
GPT teacher head0.282
Teacher spread0.250 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

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