Additional file 1 of TSPO PET detects acute neuroinflammation but not diffuse chronically activated MHCII microglia in the rat
Bibliographic record
Abstract
Additional file 1.: Online Fig. 1 SUV was significantly different between the pseudoreference regions, cerebellum and PAG, in wild-type and TgAPP21 [F(1,21) = 53.30, P < .0005, two-way ANOVA]. Whole brain SUV is also shown. CIR: contralateral to the infarct region. PAG: periaqueductal gray. Error = SD. Online Fig. 2 Wild-type saline and ET1 rat pseudoreference regions at baseline, day 7, and day 28 after an injection in the right dorsal striatum. (A) SUV maps overlaid on T2-weighted MRI. (B) SUV showed a significant effect of region [F(1,21) = 53.30, P < .0005, two-way ANOVA]. CIR, contralateral to the infarct region; PAG, periaqueductal gray. Error = SD. Online Table 1 SUV (mean ± SD) in the pseudoreference regions of wild-type saline and ET1 rats at baseline, day 7, and day 28 after an injection in the right dorsal striatum. SUV was not significantly affected by genotype, ET1, or interaction between ET1 and timepoints (P = ns for two-way and three-way ANOVA). Region was a significant factor (F(2,12) = 27.47, P = 0.001, three-way ANOVA). Online Fig. 3 Correlations of distribution volume with distribution volume ratio to candidate pseudoreference regions. Each point represents one region in one Wt rat at the 28 day post-stroke timepoint. The coefficients of determination are provided in the graph. CIR, contralateral to the infarct region; PAG, periaqueductal gray. Online Fig. 4 Correlations of infarct TSPO immunohistochemistry to uptake ratios calculated using candidate pseudoreference regions. Regression coefficients are provided in the graph. CIR, contralateral to the infarct region; PAG, periaqueductal gray; IR, Infarct region. Online Fig. 5 TSPO Immunohistochemistry of WM at day 7 and day 28 in saline and ET1 rats. (A) Representative images and (B) quantification of cell count for TSPO. FM, Forceps Minor; CC, corpus collosum; i, ipsilateral; c, contralateral; p, posterior. Bar indicates 100 µm. Error = SD.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.009 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.832 | 0.149 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".