Additional file 1 of 14-3-3 $$\upzeta /\updelta$$ ζ / δ -reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2
Bibliographic record
Abstract
Additional file 1: Table S1. LC–MS settings. LC–MS settings including electrospray and iFunnel for the analysis of the synaptic protein panel. Table S2. Odds ratio analyses to predict 14-3-3 $$\upzeta /\updelta$$ ζ / δ . OR = Odds ratio, CI = Confidence interval (up = 95%, low = 5%), GFAP = glial fibrillary acid protein, sTREM2 = soluble triggering receptor expressed in myeloid cells 2 (sTREM2). Table S3. SEM indices of goodness of fit. CFI = Comparative Fit Index, RMSEA = Root Mean Square Error of Approximation, SRMR = Standardized Root Mean Square Residual, TLI = Tucker Lewis Index, AD = Alzheimer’s Disease. Figure S1. 14-3-3 $$\upzeta /\updelta$$ ζ / δ is associated with memory deficits in cognitively unimpaired. (A) CSF levels of 14-3-3 $$\upzeta /\updelta$$ ζ / δ in A-T-N-, A + T-N-, A + T + N-, and A + T + N + , cognitively unimpaired young individuals were excluded for this analysis. Wilcoxon test with FDR-correction for multiple comparisons was used for statistical comparisons. * P < 0.05, *** P < 0.001. (B-C) CSF levels of 14-3-3 $$\upzeta /\updelta$$ ζ / δ in CU (B) and CI (C) participants divided by APOE ε4 carriership. (D-E) Spearman correlation analyses between CSF levels of 14-3-3 $$\upzeta /\updelta$$ ζ / δ and RAVLT immediate score (D) and delayed score (E) in cognitively unimpaired and impaired participants. Exact P-values and correlation coefficients are shown in the figure. Figure S2. Astrogliosis and microglia activation are detectable in early disease. (A–C) Plasma GFAP levels (A), whole brain [11C]PBR28 SUVR (B) and CSF sTREM2 (C) levels in A–T–N–, A + T–N–, A + T + N–, and A + T + N + according to the A/T/N framework using [18F]AZD4694, [18F]MK6240 and hippocampal volume. Wilcoxon test against A–T–N– with FDR-correction for multiple comparisons were conducted. *P < 0.05, **P < 0.01, ***P < 0.001.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.958 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".