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Additional file 1 of Epigenetic silencing and genome dynamics determine the fate of giant virus endogenizations in Acanthamoeba

2025· article· en· W6902329630 on OpenAlexaff

Bibliographic record

VenueOpen MIND · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicLegionella and Acanthamoeba research
Canadian institutionsDalhousie University
Fundersnot available
KeywordsAcanthamoebaIntergenic regionContext (archaeology)GenomeSyntenyGene silencingMobile genetic elements

Abstract

fetched live from OpenAlex

Additional file 1. Figures S1–S8. Word document. Fig. S1 Synteny between Neff and C3 chromosomes. Fig. S2 Phylogeny of serine/threonine kinase endogenized into the Neff genome. Fig. S3 Distance from chromosome ends of genomic features in Neff and C3. Fig. S4 Detailed characterization of representative viral insertions in Acanthamoeba str. Neff. Fig. S5 Mobile element diversity based on genomic context in Neff and C3. Fig. S6 Methylation level of genes, mobile elements, and intergenic regions in Acanthamoeba strains Neff and C3. Fig. S7 Methylation level of viral genes and regions in Acanthamoeba strains Neff and C3. Fig. S8 Comparison of Nanopolish and Enzymatic Methyl-seq analyses.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.009
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.805
Threshold uncertainty score0.278

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.009
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0030.005
Science and technology studies0.0020.000
Scholarly communication0.0020.002
Open science0.0030.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.8050.192

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.018
GPT teacher head0.277
Teacher spread0.260 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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