Mechanism of Ion Transport\nby Fluorescent Oligoester\nChannels
Bibliographic record
Abstract
The synthesis and membrane activity of a suite of linear\noligoesters\ncontaining a common diphenylacetylene unit core and differing in the\nhydroxyl terminus are reported. Active compounds formed high-conductance\nchannels efficiently in both vesicle and planar bilayers, with one\ncompound showing a very unusual slow loss of transport activity over\na 20–30 min period. Steady-state and time-resolved fluorescence\nstudies establish the rapid partition of active compounds to the bilayer\nand identify at least three types of membrane-associated species by\ntheir differing fluorescence lifetimes. The change in the distribution\nof species is correlated with the slow loss of activity. The results\nare interpreted in terms of an aggregate within a single bilayer leaflet\nthat is nonetheless competent to transport ionic species through the\nbilayer. The properties of such structures, revealed by these compounds,\nappear to be consistent with commonly observed behaviors of other\nsynthetic ion channels.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.214 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".