Additional file 4 of Optical mapping of human embryonic stem cell-derived cardiomyocyte graft electrical activity in injured hearts
Bibliographic record
Abstract
Additional file 4: Supplementary Fig. S4. Simultaneous di-2-ANEPEQ imaging and direct electrode recording of hESC-CM graft electrical activity. A cryoinjured heart with hESC-CM graft (H7 line) was impaled with a sharp electrode within the graft tissue to correlate the di-2-ANEPEQ-derived voltage signal with direct intracellular voltage recordings. A: Epicardial still image taken on the di-2-ANEPEQ channel, showing the uncoupled hESC-CM graft footprint (yellow dotted line) inside the cryoinjury region (white dotted line) and the recording electrode positioned in graft tissue. Two ROIs are indicated: one in host myocardium outside the cryoinjury zone and one in hESC-CM graft tissue overlying the tip of the recording electrode. B: Simultaneously acquired oAPs for these two ROIs, as well as the simultaneously acquired direct voltage and ECG recordings. Note the excellent temporal correlation between the direct electrode recordings and di-2-ANEPEQ-derived oAPs from this hESC-CM graft, which was uncoupled from the host.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.295 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".