Additional file 1 of Overexpressed WDR3 induces the activation of Hippo pathway by interacting with GATA4 in pancreatic cancer
Bibliographic record
Abstract
Additional file 1: Fig. S1. YAP1 overexpression reversed the inhibition in the aggressive behavior of pancreatic cancer cells induced by WDR3 silencing in vitro. Fig. S2. WDR3 expression was positively correlated with YAP1 expression in pancreatic cancer patient specimens. Fig. S3. WDR3 silencing enhanced the anti-pancreatic cancer effect of TED-347 treatment in the orthotopic syngeneic model of pancreatic cancer. Fig. S4. LC-MS/MS assay to identify the base peak of IgG IP and WDR3 IP samples. Fig. S5. GATA4 silencing reversed the induction in the aggressive behavior of pancreatic cancer cells induced by WDR3 overexpression in vitro. Table S1. The primer sequences for RT-qPCR. Table S2. The shRNA sequences. Table S3. The primer sequences for ChIP-qPCR.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.014 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.876 | 0.183 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".