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Additional file 1 of The impact of community-wide, mass drug administration on aggregation of soil-transmitted helminth infection in human host populations

2020· article· en· W6920737391 on OpenAlexaff

Bibliographic record

VenueFigshare · 2020
Typearticle
Languageen
FieldImmunology and Microbiology
TopicParasites and Host Interactions
Canadian institutionsSickKids FoundationHospital for Sick Children
Fundersnot available
KeywordsMass drug administrationAscaris lumbricoidesHost (biology)Drug administrationRandom effects modelFood and drug administrationHelminths

Abstract

fetched live from OpenAlex

Additional file 1: Figure S1.A. lumbricoides prevalence over time (a–c) and aggregation (parameter k) over time (d–f), in this plot we show 500 out of 1000 simulated villages. a and d: Random non-compliance; b and e: Semi-systematic non-compliance; c and f: Fully systematic non-compliance. Figure S2. Age-prevalence over time for a selected village in which elimination of A. lumbricoides infection was not achieved before mass drug administration was implemented (a) and post-MDA and one in which elimination was not achieved (b). Age groups (years): 1, 0–5; 2, 6–10; 3, 11–15; 4, 16–30; 5, 31–50; 6, 51+. Figure S3. The proportion of individuals who still harbour worms, either hookworm (a) or A. lumbricoides (b) after each round of mass drug administration (T1–5) for random compliance, semi-systematic compliance and systematic compliance. Figure S4. The proportion of individuals who harbour both male and female worms (A. lumbricoides) and produce fertile eggs (grey shaded color) and the proportion of individuals who harbour either only male or only females worms and produce no fertile eggs (orange shaded color) for random compliance (a), semi-systematic compliance (b) and systematic compliance (c). Figure S5. Results from analytical approach for predicting change in aggregation after treatment under semi-systematic non-compliance. a Comparison of mean worm burden observed from the stochastic model immediately post-treatment and that expected from the simple probability model. b Comparison of k observed from the stochastic model and that expected from the simple probability model immediately post-treatment. Note: For a, the gray line represents the equation x = y (perfect agreement).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.034
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.842
Threshold uncertainty score0.226

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.034
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.003
Science and technology studies0.0010.000
Scholarly communication0.0020.002
Open science0.0020.001
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.8420.088

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.047
GPT teacher head0.318
Teacher spread0.271 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2020
Admission routes1
Has abstractyes

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