Additional file 1 of Saturated very long-chain fatty acids regulate macrophage plasticity and invasiveness
Bibliographic record
Abstract
Additional file 1: Figure S1. Flow cytometric analysis of CD14+ cell purity. Figure S2. Interactomes integrating dysregulated inflammatory response genes and protein–protein interactions related to cell surface receptors, plasma membrane proteins or G-protein coupled receptors in monocyte-derived macrophages from X-ALD patients versus healthy controls. Figure S3. Viability staining to evaluate cytotoxicity of C26:0 treatment in human primary macrophages. Figure S4. Inhibition of CD36 by SSO co-treatment reduces activation of the JNK pathway in C26:0-exposed macrophages. Figure S5. Pro-inflammatory IL1B, TNF and IL6 cytokine expression is not significantly stimulated by VLCFA C26:0 treatment. Figure S6. C26:0 treatment affects chemokine release by human primary macrophages. Figure S7. Podosome formation in human primary macrophages treated with C26:0. Table S1. Primers used for RT-qPCR analysis
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.019 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.903 | 0.236 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".