Additional file 1 of MiR-34c downregulation leads to SOX4 overexpression and cisplatin resistance in nasopharyngeal carcinoma
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
The three-model screen
all 1,000 screened works →All three models called this out of scope.
Supplementary figure file for a cancer biology paper on miR-34c and cisplatin resistance.
This is a supplementary molecular-biology figure file and does not study research itself.
Supplementary figure file for a cancer molecular paper; domain biomedical content.
Abstract
Additional file 1: Figure S1. (A) Relative miR-34c expression assessed by qRT-PCR in C666–1 cells treated with SB431542 (10 or 20 μM) for 72 h compared to untreated cells (UT). (B and C) Relative expression of putative miR-34c targets assessed by qRT-PCR in NP69, NP460, and C666–1 cells, normalized to C666–1 cells. (B) Genes that are highly expressed in C666–1 (NPC) cells vs. NP69 and NP460 (normal nasopharyngeal) cells. (C) Genes with no significant differences in expression between C666–1 cells and NP69/NP460. Note that MARCKS and PML expression were significant only between C666–1 and NP460 cells. The data are represented as the mean ± SEM of at least three independent experiments. * P < 0.05; ** P < 0.01; *** P < 0.001.
Stored with the screening record, where it is evidence for the labels above.
The record
- Venue
- Figshare
- Topic
- MicroRNA in disease regulation
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- Princess Margaret Cancer CentreUniversity of TorontoUniversity Health Network
- Funders
- —
- Keywords
- Downregulation and upregulationNasopharyngeal carcinomaGeneCell cultureGene expressionSOX4ImmunohistochemistryMARCKS
- Has abstract in OpenAlex
- yes