Additional file 4 of A novel mechanism of phenotypic heterogeneity in Creutzfeldt-Jakob disease
Bibliographic record
Abstract
Additional File 4: Figure S2. Calibration of the mass spectrometric method for determination of relative concentrations of 129 M and 129 V PrP in mixtures containing different proportions of both proteins. a: Calibration data for recombinant human PrP (rhuPrP) using five different mixtures of 129 M and 129 V rhuPrP with concentrations of each protein determined by absorbance at 280 nm. b: Calibration data for resPrPD purified from pure cases of sCJDMM2 and sCJDVV2 using five different proportions of 129 M and 129 V resPrPD with concentrations of each protein determined by densitometric analysis of Western blots. In each case, the mixtures were digested with trypsin and analyzed by mass spectrometry. Spectral counting method was used to determine the relative proportions of 129 M and 129 V PrP polymorphs.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.045 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.003 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.892 | 0.187 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".