Additional file 2 of Biological basis of extensive pleiotropy between blood traits and cancer risk
Bibliographic record
Abstract
Additional file 2: Fig. S1. Blood trait associations with cancer diagnosis in the first year. Fig. S2. Genetic correlations among blood traits and cancer risk. Fig. S3. Q-Q plots for the genetic comparisons between blood traits and cancer risk. Fig. S4. Pleiotropic variant in a RNY-transcribed sequence. Fig. S5. RNY signatures and age of diagnosis of cancer types in TCGA. Fig. S6. Phylogenetic analysis of RNY sequences from the human genome. Fig. S7. The individual profiles of RNYs in plasma do not predict breast cancer. Fig. S8. General RNY overabundance in plasma is associated with breast cancer development. Fig. S9. Absence of association between levels of miRNAs known to be abundant in human plasma and breast cancer development.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.034 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.004 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.886 | 0.157 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".