Additional file 7 of Delineating three-dimensional behavior of uveal melanoma cells under anchorage independent or dependent conditions
Bibliographic record
Abstract
Additional file 7: Figure S7. Diverse morphological adaptation of UM cells on anchorage dependent culture conditions. (A) Representative phalloidin/DAPI images of MEL270, OMM2.5, and MP46 cell cultures. Arrowheads indicating clusters of irregular shapes, and different sizes. Arrows depicting few cells from OMM2.5 and MP46 that are capable to stretched acquiring a mesenchymal phenotype. (B-D) UM maintained the expression of MelanA and HMB45 markers when cultured under anchorage dependent. (B) Representative immunofluorescence microscopy images of MelanA expression on UM cells maintained under 2D culture condition. UM cells grown in 2D conditions adopted different shape phenotypes. Top panels: 92.1, MEL285, and MP46 cells adopted elongated fibroblastic-like cytoplasmic projections. Low panels MEL270, OMM2.5 and MP41 had an epithelioid phenotype. (C) Representative immunofluorescence microscopy images of HMB45 expression under 2D culture condition. (D) UM cells arrangements on AD-3D on top, immunofluorescence microscopy images displaying expression of melanocytic markers MelanA and HMB45.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.022 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.894 | 0.251 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".