Direct\nDetection of the Gel–Fluid Phase Transition\nof a Single Supported Phospholipid Bilayer Using Quartz Crystal Microbalance\nwith Dissipation Monitoring
Why this work is in the frame
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Bibliographic record
Abstract
Supported phospholipid bilayers (SPBs)\nare valuable models for\nfundamental studies of biological membranes and their interaction\nwith biologically relevant solutes or particles. Herein, we demonstrate\nthe capability of the quartz crystal microbalance with dissipation\nmonitoring (QCM-D) to directly detect the gel–fluid phase transition\nof a SPB. The approach involves comparison of the frequency response\nof a bare and a bilayer-coated QCM-D crystal during linear temperature\nvariation. Phase transition results in a change of the resonance frequency\nthat coincides directly with the accompanied change in bilayer thickness\ndetected by ellipsometry. Experiments performed at different heating\nrates further demonstrate the use of dissipation monitoring to determine\nthe phase transition temperature based on the temperature-induced\nviscosity changes of the ambient medium in the immediate environment\nof the bilayer. Unlike other methods, the proposed approach enables\nprecise determination of the phase transition of a SPB without the\nneed for thermal equilibration of the measurement chamber and, thus,\nhas great potential for sensitive detection of structural and/or compositional\nchanges of the bilayer.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it