Helical Structure of Disodium 5′-Guanosine Monophosphate Self-Assembly in Neutral Solution
Bibliographic record
Abstract
Supporting Information Materials and MethodsHydrated disodium salt of guanosine 5-monophosphate (purity > 99%) was obtained from Sigma-Aldrich (Ontario, Canada).All NMR spectra were acquired on Bruker Avance-500 (11.7 T) and Avance-600 (14.0 T) spectrometers.Standard solution NMR methods such as 1 H DOSY, DOSY-NOESY, ROESY, TOCSY, DQF-COSY, 1 H-13 C HSQC, 1 H-13 C HMBC, refocused 1 H-13 C HMBC, and 1 H-31 P COSY experiments were used for spectral assignment and structure determination.Experimental details are given in the Supplementary Information.Quantum chemical calculations of NMR parameters such as chemical shielding and indirect spin-spin coupling constants were performed on a Sun Fire cluster using the Gaussian 03 suite of programs 28 .The Sun Fire cluster is comprised of seven Sun Fire 25000 servers.Each of the Sun Fire 25000 servers is equipped with 72 (2 MB on-chip L2 cache and 32 MB L3 cache) dualcore (CPU) UltraSPARC-IV+ processors and 576 GB of RAM.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.046 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".