The molecular mechanisms regulating the expression of acetylcholinesterase in cholinergic neurons.
Bibliographic record
Abstract
Acetylcholinesterase (AChE) is responsible for the rapid hydrolysis of acetylcholine into acetic acid and choline, thereby ensuring precise temporal control of synaptic transmission. The role of AChE has been well documented with respect to the neuromuscular junction where it performs this classic function. However, it has recently been discovered that AChE is also expressed in a variety of non-cholinergic tissues such as haematopoietic cells and selected populations of neurons. The role of the enzyme in non-cholinergic neuronal cells is currently unknown and its regulation in this population of cells has been generally overlooked. In this study, we established a cell model to study the developmental and trophic regulation of AChE in neuronal cells. In addition, we examined the regulation of the acetylcholine-synthesizing enzyme, choline acetyltransferase (ChAT) to elucidate the relationship between the two cholinergic enzymes. In a first series of experiments, we tested several hybrid cell lines for AChE activity. Next, we examined the developmental regulation of AChE and ChAT using NSC-34 motoneurons. (Abstract shortened by UMI.)
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".