Mediterranean Diet and Associations with the Gut Microbiota and Pediatric-Onset Multiple Sclerosis: a Trivariate Analysis
Bibliographic record
Abstract
Abstract The interplay between diet and the gut microbiota in multiple sclerosis (MS) is poorly understood. We conducted a case-control study to assess an interrelationship between diet, the gut microbiota, and MS by including 95 participants (44 pediatric-onset MS cases, 51 unaffected controls) enrolled from the Canadian Pediatric Demyelinating Disease Network study. All had completed a food-frequency questionnaire ≤ 21-years of age, and 59 also provided a stool sample. A 1-point increase in a Mediterranean diet score was associated with 37% reduced MS odds (95%CI: 10–53%). Higher fiber and iron intakes were also associated with reduced MS odds. Diet, not MS, explained inter-individual gut microbiota variation. Several gut microbes abundances were associated with both the Mediterranean diet score and MS presence, and these microbes were potential mediators of the protective associations of a healthier diet. Findings suggest that the potential interaction between diet and the gut microbiota is relevant in MS.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".