Additional file 2 of Early peripheral blood gene expression associated with good and poor 90-day ischemic stroke outcomes
Bibliographic record
Abstract
Additional file 2: Figure S2. Top 20 most significant pathways enriched with genes whose expression correlates with 90-day NIHSS at ≤ 3 h, 5 h and 24 h. The top 20 most significant activation or suppression relevant pathways are displayed. Blue shading indicates suppression (negative Z-score), orange indicates activation (positive Z-score), and darker colors represent larger |Z-score|. ↑ (up arrow) represents Z ≥ 2, significant activation and ↓ (down arrow) represents Z ≤ − 2 significant suppression in participants with worse outcome compared to participants with better 90-day outcome. The asterisk * represents a statistically significant pathway (P < 0.05). White cells represent activity pattern prediction of Z = 0 (suppression or activation status cannot be predicated). Grey represents no activity pattern available for the pathway in the IPA knowledge base. Reg. Regulation, Expr. Expression, Lymph. Lymphocytes, Cyt. Cytotoxic
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.021 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.843 | 0.133 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".