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Record W6939438847 · doi:10.6084/m9.figshare.25150727

Additional file 2 of The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth

2024· other· en· W6939438847 on OpenAlexaff

Bibliographic record

VenueFigshare · 2024
Typeother
Languageen
FieldAgricultural and Biological Sciences
TopicMycorrhizal Fungi and Plant Interactions
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsGene knockdownRegulatorWestern blotCell growthComplementary DNACellPhosphataseMessenger RNA

Abstract

fetched live from OpenAlex

Additional file 2. Figure S2. Additional growth assays in TNBC. (A) The efficiency of siRNA knockdown in Fig. 2A is demonstrated by Western blot and qPCR data from samples collected on day 1 (shown in this Supplementary Figure) and day 7 (also shown in Fig. 2). Shown are the results of one experiment for each cell line. This experiment was repeated and the results showed similar siRNA knockdown and TNBC growth suppression results. (B) MDA-MB-436 NUDT5 ORF cDNA overexpressing cells treated with siRNA targeting the 3’UTR region of NUDT5 mRNA is shown. siRNA knockdown efficiency is shown by Western blot analysis. The significant differences between day 7 cell counts were determined using Student t test (ns, not significant; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.016
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.896
Threshold uncertainty score0.148

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.016
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0020.003
Science and technology studies0.0010.000
Scholarly communication0.0020.002
Open science0.0020.001
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.8960.298

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.231
Teacher spread0.214 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designBench or experimental
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

Explore more

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