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Record W6939457238 · doi:10.6084/m9.figshare.12386411

Additional file 5 of Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington’s disease

2020· article· en· W6939457238 on OpenAlexaff

Bibliographic record

VenueFigshare · 2020
Typearticle
Languageen
FieldNeuroscience
TopicGenetic Neurodegenerative Diseases
Canadian institutionsUniversity of Calgary
Fundersnot available
KeywordsBurstingInterval (graph theory)Premovement neuronal activityNetwork topologyTopology (electrical circuits)NeuronLine (geometry)Statistical analysis

Abstract

fetched live from OpenAlex

Additional file 5: Figure S5. Quantification of individual spontaneous activity in WT and HD striatal and cortical primary cultures. (A-E) Single neuron statistics. (A) Activity rate, i.e., average spikes per second of each neuron. (B) Inter-spike interval (ISI), i.e., average time between two consecutive spikes. (C) Bursting rate, i.e., frequency of single-cell bursts. (D) Average inter-burst interval (IBI), average time between consecutive individual bursts (STR WT n=38; STR HD n=37; CTX WT n= 19; CTX HD n=22). Each dot represents a single experiment, thick line the mean, thick shaded area the Standard Error of the Mean and thin shaded area the standard deviation. Statistical analysis was performed using Student t-test. * p< 0.05, ** p<0.01 compared to WT.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.021
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.911
Threshold uncertainty score0.127

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.021
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0020.003
Science and technology studies0.0010.000
Scholarly communication0.0020.002
Open science0.0020.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.9110.184

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.039
GPT teacher head0.247
Teacher spread0.208 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2020
Admission routes1
Has abstractyes

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