Apical-Out Airway Organoids can be utilised to study antiviral effects on enterovirus-D68 (EV-D68) infection
Bibliographic record
Abstract
(A) Viral load of EV-D68 detected by qPCR in the supernatant in the presence and absence of itraconazole (ITZ). Points represent mean values. Error bars represent the SD. Double asterisks indicate p < 0.01 and three asterisks p < 0.001. (n = 3). (B) Viral load of EV-D68 detected by qPCR in the supernatant in the presence and absence of rupintrivir (RUP). Points represent mean values. Error bars represent the SD. Double asterisks indicate p < 0.01 and three asterisks p < 0.001. (n = 3). (C) Relative Fluorescent Units (RFU) measured at 72 hpi indicating changes in viability of Ap-O AO following infection with EV-D68 in the presence or absence of ITZ and RUP. Single points represent the mean with SEM. Single asterisks indicate p < 0.05, double asterisks p < 0.01 and three asterisks p < 0.001. (n = 3). (D) Representative images (Donor 2) showcasing the CPE observed in Ap-O AO following infection with EV-D68 without antiviral treatment (top row) and with addition of ITZ (middle row) or RUP (bottom row). (scale bars = 300 μm).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.003 |
| Insufficient payload (model declined to judge) | 0.005 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".