Additional file 2 of Evaluating the association of biallelic OGDHL variants with significant phenotypic heterogeneity
Bibliographic record
Abstract
Additional file 2: Fig. S1. Validation of CRISPR-induced indels in ogdhl mutant and F0 knockout animals. Fig. S2. OGDHL protein orthologs alignment. Fig. S3. Temporal expression profiles of ogdh paralogs and the tissue-specific expression of OGDHL/ogdhl across species. Fig. S4. Genetic compensation in zebrafish ogdhl mutant.Fig. S5. Knockout upf3a in ogdhl-/- mutant elicits disease-associated phenotypes and mitigates the expression of compensated gene. Fig. S6. Analysis of the ogdh members’ expressions in respective F0 knockouts, body length and startle behaviors. Fig. S7. Analysis of exogenous human OGDHL or OGDH expression in co-injected embryos. Fig. S8. Analysis of cell apoptotic gene expression in embryos lacking Ogdhl. Fig. S9. Molecular modeling of OGDHL variants. Fig. S10. Analysis of human OGDHL variants’ expression in co-injected embryos.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.026 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.846 | 0.156 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".