Additional file 3 of Analysis of the microglia transcriptome across the human lifespan using single cell RNA sequencing
Bibliographic record
Abstract
Additional file 3: Figure S3. Pre-natal microglia have distinct transcription factor activity compared to post-natal cells. A) SCENIC plot depicting unbiased microglia clustering according to inferred TF activity separated by cluster. B) Heatmap showing the activity of 142 identified TFs during SCENIC analysis. The activity score of TFs is represented by color coded z-score. C) SCENIC plot representing mRNA expression and binary regulon activity of SPI1 TFs inferred by SCENIC. Expression of genes is represented by a color gradient in which orange means high expression and grey means no expression. Activity is represented by a binary index in which blue means active and grey means inactive. D) PCA plot of human and mouse microglia at different ages without human oligodendrocyte samples. Pre.n = Pre-natal, Ped. = Pediatric, Ado. = Adolescent, Adu. = Adolescent, H-OL = Human Oligodendrocyte.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.014 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.805 | 0.230 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".