Additional file 1 of The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons
Bibliographic record
Abstract
Supplementary Material 1. Supplementary Table 1: QTL datasets used for analyses. Supplementary Table 2. Study population. Supplementary Table 3: Coverage details for CTSB. Supplemental Table 4: Primer and gRNA sequences used in the generation of CTSB-KO iPSC lines. Supplementary Table 5: Cell Culture Reagents and Media Compositions. Supplemental Table 6: CRISPRa and CRISPRi gRNA sequences. Supplemental Table 7: Antibodies. Supplemental Table 8: qPCR Primer sequences. Supplementary Table 9: GCTA-COLOC results. Supplementary Table 10: FINEMAP results of the nominated variants in CTSB. Supplementary Table 11: CTSB locus SMR and HEIDI analyses. Supplemental Table 12: Burden analysis for CTSB rare variants. Supplemental Table 13: gnomAD CTSB LOF. Supplemental Table 14: gnomAD SV CTSB.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.009 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.407 | 0.098 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".