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Record W6958118375 · doi:10.6084/m9.figshare.12569162

Additional file 3 of MiR-34c downregulation leads to SOX4 overexpression and cisplatin resistance in nasopharyngeal carcinoma

2020· article· en· W6958118375 on OpenAlexaff

Bibliographic record

VenueFigshare · 2020
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicMicroRNA in disease regulation
Canadian institutionsPrincess Margaret Cancer CentreUniversity of TorontoUniversity Health Network
Fundersnot available
KeywordsDownregulation and upregulationSOX2Nasopharyngeal carcinomaViability assayCisplatinCell cultureCellSOX4

Abstract

fetched live from OpenAlex

Additional file 3: Figure S3. (A) Relative SOX4 and SOX2 expression assessed by qRT-PCR in NP69 cells stably overexpressing SOX4. (B) Relative SOX2 expression assessed by qRT-PCR in C666–1 cells stably expressing pre-miR-34c. (C, D, and E) Cell viability was measured by ATPlite assay 72 h after cisplatin treatment: (C) Stable C666–1-anti-miR-34c (or control) cells. (D) Stable NP69-pre-miR-34c (or control) cells. (E) Stable NP460-pre-miR-34c (or control) cells. (F) Effect of SB431542 on C666–1 cell viability measured by ATPlite at 72 h. The data are represented as the mean ± SEM of at least three independent experiments. * P < 0.05; ** P < 0.01; *** P < 0.001.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.018
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.917
Threshold uncertainty score0.118

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.018
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0020.003
Science and technology studies0.0010.000
Scholarly communication0.0020.002
Open science0.0020.001
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.9170.208

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.230
Teacher spread0.215 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2020
Admission routes1
Has abstractyes

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