Additional file 5: of DNA methylation in the APOE genomic region is associated with cognitive function in African Americans
Bibliographic record
Abstract
Figure S2. Correlation of blood and brain methylation for the eight CpG sites significantly associated with delayed recall in GENOA: Results from Blood-Brain Epigenetic Concordance (BECon). Comethylation plots showing the methylation levels in blood and three cortical regions (Broadmann area 10 (BA10), prefrontal cortex; Broadmann area 7 (BA7), parietal cortex; and Broadmann area 20 (BA20) temporal cortex) in 16 individuals ranging from 15 to 87 years of age from the Douglas-Bell Canada Brain Bank (panel 1), as well as a summary of blood-brain correlations (Spearman correlation value), variability of the CpGs (range of beta values between 10th and 90th percentile in the sample), and the effect of cell composition (change in beta value before and after adjustment for cell composition) (panel 2). Plots were generated from the Blood-Brain Epigenetic Concordance database ( https://redgar598.shinyapps.io/BECon/ ). Only CpG sites that showed a significant association with delayed recall (FDR q < 0.1) in the GENOA sample were investigated. (PDF 21 kb)
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.022 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.830 | 0.070 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".