Additional file 1 of Insulator-based loops mediate the spreading of H3K27me3 over distant micro-domains repressing euchromatin genes
Bibliographic record
Abstract
Additional file 1: Figure S1. Genomic contexts of the influence of Beaf32 on H3K27me3 spreading. Figure S2. Validation of micro-domains by quantitative PCR analysis of ChIP. Figure S3. Regulation of H3K27me3 spreading by Beaf32 and CP190 and depending on genomic contexts. Figure S4. Regulation of long-range interactions by insulator proteins. Figure S5. Beaf32 depletion affects specific insulator-based LRIs by Beaf32, GAF, dCTCF and CP190. Figure S6. Beaf32 looping mutants alter H3K27me3 levels in micro-domains involving regulation of CP190 recruitment. Figure S7. Regulation of H3K27me3 trans-spreading may contribute to co-regulate specific gene functions through development.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.013 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.900 | 0.270 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".