Additional file 1 of Thyroid hormone protects human lung epithelial cells from cold preservation and warm reperfusion-induced injury
Bibliographic record
Abstract
Additional file 1: Figure S1. Short cold preservation and warm reperfusion activates genes related to inflammation. A) A cell culture model that simulates cold preservation and warm reperfusion in lung transplantation. B) After 6 h cold preservation (clinically used condition), gene clusters related to inflammation were enriched during warm reperfusion in human lung epithelial BEAS-2B cells, which is also associated with the down-regulation of genes related to protein synthesis. Figure S2. A) Experimental design. Cells were treated with or without T3 (2.5 μM) or T4 (25 μM) for 6 h or 18 h cold preservation, followed by 4 h warm reperfusion. Gene expression was assessed with NanoString for pathways associated with human organ transplantation. B) Compared with no-IR treated cells, IR-exposed cells had increased expression in interferon signalling and virus defence pathways. C and D) Reperfusion had minimum effects on differential gene expression in T3 and T4 treated cells, respectively.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.024 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.004 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.901 | 0.208 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".