Functional Characteristics and Lipid Lowering Activity of Auricularia heimuer Soluble Dietary Fiber
Bibliographic record
Abstract
In this study, the residue of Auricularia heimuer polysaccharide after hot water extraction was used as raw material, and the soluble dietary fiber (HSDF) of A. heimuer was extracted by compound enzyme method. Its molecular weight, monosaccharide composition and sugar chain composition were analyzed, its water holding capacity, oil holding capacity, swelling power and other physical and chemical properties were detected, and its lipid-lowering activity in vitro was evaluated by measuring cholesterol adsorption capacity, lipase inhibition rate and cholate binding rate. The obese animal model was constructed by high fat diet (HFD) C57BL/6J mice, and treated with A. heimuer soluble dietary fiber. The body weight, biochemical indexes, and pathological changes of liver tissue and adipose tissue of HSDF treated obese mice were evaluated, and its lipid-lowering efficacy in obese mouse model was explored. Results showed that the relative molecular weight of HSDF was 4.14×105 Da, which was a mixture of mannose, glucuronic acid, glucose, galactose, xylose and fucose. The molar ratio was 1808.87:0.00278:4.43:2.13:2.84:5.01. The average water holding capacity of HSDF was (11.62±0.302) g·g−1, the average oil holding capacity was (2.95±0.259) g·g−1, the average swelling capacity was (12.7±0.434) mL·g−1, and the adsorption capacity of intestinal cholesterol was 6.63 mg·g−1. When the concentration was 1.2 mg·mL−1, the binding rate of sodium glycocholate and sodium taurocholate could reach 92.91% and 90.93%. In addition, HSDF with a concentration of 2.0 mg·mL−1 had a 75% inhibition rate of pancreatic lipase, and had good lipid-lowering activity in vitro. At the same time, HSDF could significantly (P<0.05) improve the organ index of HFD mice, improve the lipid accumulation, inflammatory cell infiltration in the liver and adipocyte enlargement in adipose tissue of HFD mice, and improve the cell area of white adipose tissue of epididymis by more than 50%, which had a good lipid-lowering effect in vivo. The results can provide data support and theoretical basis for the subsequent research on dietary fiber of A. heimuer and the research and development of functional food.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".