The presence of intraductal carcinoma of the prostate and adjacent usual invasive prostate cancer detected by Raman micro-spectroscopy.
Bibliographic record
Abstract
<p>(A) Standard histology immunostaining for high molecular weight cytokeratins and p63 (basal cell markers in brown) and α-methylacyl-CoA racemase (cancer cell marker in red), followed by hematoxylin and eosin (H&E) counterstaining to identify intraductal carcinoma of the prostate (IDC-P) along with adjacent cancer and prostate cancer without IDC-P. An adjacent 4-μm tissue section on an aluminum slide was used to target a precise location for Raman micro-spectroscopy (RμS) on unstained prostate tissue. (B) Average Raman spectra of IDC-P with adjacent cancer (15 patients; 112 spectra) and prostate cancer (272 patients; 1,088 spectra) from the Centre hospitalier de l’Université de Montréal (CHUM) cohort. Raman peaks (i.e., biochemical constituents of tissue) that were dominant contributors to the classification are identified with dotted gray lines. Bottom frame shows the standardized Raman spectra, where each individual feature has 0 mean and unit variance. Spectra with their respective variance are shown in <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1003281#pmed.1003281.s006" target="_blank">S6B Fig</a>.</p>
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.006 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".