Relationship between Serum Matrix Metalloproteinase-8 and Periodontitis: A PRISMA-Compliant Systematic Review and Meta-Analysis
Bibliographic record
Abstract
To determine whether serum matrix metalloproteinase-8 (MMP-8) level is elevated in periodontitis patients comparing to periodontally healthy subjects, we conducted a meta-analysis to assess its diagnostic value. This study aims to provide some enlightenment for solving the problem of higher prevalence and severity of systematic diseases in periodontitis patients, as well as help recognizing the potential of serum MMP-8 in the rapid diagnosis of periodontitis. A comprehensive search of Pubmed, Embase and Cochrane Library was conducted to retrieve comprehensive relevant articles. The methodological qualities of the included articles were evaluated following Newcastle-Ottawa Scale (NOS) grading system. The level of serum MMP-8 was converted to standard forms (Mean ± SD) and me-ta-analysis was conducted by Review Manager 5.4 software. Sensitivity analyses were performed by Stata 17.0 software. Our meta-analysis aims to help to show that serum MMP-8 level in periodontitis patients is higher than that in healthy subjects or not.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.025 | 0.052 |
| Meta-epidemiology (narrow) | 0.003 | 0.002 |
| Meta-epidemiology (broad) | 0.018 | 0.035 |
| Bibliometrics | 0.008 | 0.009 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.004 | 0.002 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".