Study of correlation between calcification regulatory factors and cognitive impairment in maintenance hemodialysis patients
Bibliographic record
Abstract
ObjectiveTo evaluate the correlation of serum dephosphorylated uncarboxylated matrix Gla protein （dp-ucMGP） and bone morphogenetic protein-2 （BMP-2） with cognitive impairment （CI） in maintenance hemodialysis （MHD） patients.MethodsTwo hundred and fifty-four MHD patients in the First Affiliated Hospital of Shihezi University and Shihezi People's Hospital from June 1， 2021 to April 30， 2023 were selected. The general and laboratory data of the patients were collected. Cognitive function was evaluated with the Chinese version of Montreal Cognitive Assessment Scale （C-MoCA）. Enzyme-linked immunosorbent assay （ELISA） was used to measure serum dp-ucMGP and BMP-2.ResultsAmong the 254 patients included， 192 patients with CI were screened by the C-MoCA scale. Patients in the CI group had significantly older age ［57.0（50.0，67.7）years vs 48.0（35.0，54.0）years］， higher systolic blood pressure ［SBP， 137（129，148）mmHg vs 134（125，142）mmHg， 1 mmHg=0.133 kPa］， female proportion （40.1% vs 22.6%）， proportion of hypertension （76.6% vs 45.2%）， years of education （≤6 years： 30.7% vs 4.8%； >6， ≤9 years： 41.2% vs 27.4%）， serum dp-ucMGP ［9.05（7.81，10.71）μg/L vs 5.95（4.43，7.21）μg/L］， and serum BMP-2［114.72（101.07，140.44）ng/L vs 89.65（74.17，101.74）ng/L］， but lower proportion of high education level （>9， <13 years： 20.3% vs 45.2%； ≥13 years： 7.8% vs 22.6%） than those in the non-CI group （P<0.05）. Binary Logistic regression analysis suggested that age， SBP and serum dp-ucMGP and BMP-2 were significantly correlated with CI in MHD patients （P<0.05）. Spearman correlation analysis showed that serum dp-ucMGP was negatively correlated with the C-MoCA score， and the scores of visuospatial/executive， attention， language， abstraction， delayed recall and orientation dimensions（P<0.05）. Serum BMP-2 was negatively correlated with the C-MoCA score， and the scores of visuospatial/executive， naming， attention， language， abstraction and delayed recall dimensions（P<0.05）.ConclusionSerum dp-ucMGP and BMP-2 are risk factors for CI in MHD patients， and their levels may be related to the severity of CI.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".