The effects of altered expression of clueless on ageing and neurodegeneration in Drosophila melanogaster
Bibliographic record
Abstract
Mitochondrial dysfunction is linked to the pathology of age-related and neurodegenerative disease, including Parkinson disease and amyotrophic lateral sclerosis. Preservation of mitochondrial function is determined by the interconnected processes governing mitochondrial homeostasis: fission, fusion, trafficking, mitophagy, and biogenesis. The Drosophila melanogaster protein Clueless and its mammalian homologue CLUH are cytoplasmic RNA-binding proteins essential for mitochondrial function that may influence all of these processes. Clueless and its homologues may act as master regulators of mitochondrial homeostasis to control these processes in response to environmental cues including stress-response signalling. The effects of altered expression of clueless in Drosophila melanogaster dopaminergic and motor neurons on ageing and neurodegeneration were examined through lifespan and climbing assays. In humans, dopaminergic neuron degeneration causes Parkinson disease, and motor neurons degeneration causes amyotrophic lateral sclerosis. Inhibited clueless expression in Drosophila melanogaster dopaminergic and motor neurons reduced early-life climbing ability, and inhibited clueless expression in motor neurons caused impaired lifespan and a more rapidly progressive loss of climbing ability with age. Inhibited expression of clueless in motor neurons therefore causes age-related disease in this model organism. RNAi-mediated clueless suppression in motor neurons is a promising novel model for investigation of the role of mitochondrial dysfunction in the pathology of amyotrophic lateral sclerosis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".