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Record W6969427806 · doi:10.5683/sp3/cckjyk

OsterlundJBC_Figure S2

2022· dataset· en· W6969427806 on OpenAlexaff

Bibliographic record

VenueBorealis · 2022
Typedataset
Languageen
Field
Topic
Canadian institutionsUniversity of Toronto
Fundersnot available
KeywordsProgrammed cell deathMeasure (data warehouse)HEK 293 cellsApoptosisCellCurve fitting

Abstract

fetched live from OpenAlex

<b> Figure S2 data </b> <br><br> Includes: <br> -Panels A,C,D,E,F additional biological replicates acquired to supplement data shown in Figure 1D and Figure 2C,D,E,F respectively. Date acquired, Cell line, and mCerulean3-donor is given within each Excel worksheet. Raw binding curve data was binned by Venus intensity. Here we provide the resulting binned data, and fitting parameters exported from GraphPad prism used to create the binding curves that were displayed in the Supplementary.<br><br> <br> AnnexinV (AnV) positivity, TMRE negativity, and/or nuclear area condensation ('SN' = 'small nuclear area') were used as a marker of cell death in panels G-H. <br> -Panel G, cell death was measured in BMK, HCT116 or BMK/HCT116 cells with BAX and BAK knocked out ('DKO'). Here we provide the mean cell death measured in Venus-positive cells from 3 biological replicates. <br><br> -In Panel H, cell death was measured in HEK293T cells and from one technical replicate, we binned data by Venus intensity as a measure of protein concentration to examine trends.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesInsufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Dataset · Consensus signal: Dataset
Teacher disagreement score0.147
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.1490.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.274
Teacher spread0.253 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designNot applicable
Domainnot available
GenreDataset

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2022
Admission routes1
Has abstractyes

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