Headache and MTHFRT677T Genotype in a Young Woman - Clinical Case
Bibliographic record
Abstract
Introduction:The MTHFRC677T polymorphism is involved in several pathologies.Objectives: We report one case of headache associated with the MTHFR T677T genotype in a woman.Observation: A 39-year-old woman was admitted in neurology department on March 12, 2012 for headaches with feet and hands parathesia for several months.The physical examination had noted a decrease in osteotendinous reflexes and an abolition of the plantar cutaneous reflex.Hamilton's 17-item depression score was 7. In the etiological investigation of probable polyneuropathy, homocysteine was 88.39 μmol/l (standard < 15 μmol/l), folates 2.34 nmol/l (standard ≥ 11 nmol/l) and vitamin B 12 132 pmol/l (standard ≥ 147 pmol/l).The aetiological investigation of this hyperhomocysteinemia revealed an MTHFRT677T genotype. Conclusion:The MTHFRT677T genotype is associated with a variety of manifestations ranging from metabolic (B 12 deficiency), headache and polyneuropathies.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".