Additional file 1 of Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining cognitive function in Alzheimer’s disease
Bibliographic record
Abstract
Additional file 1. Fig. S1: GABAergic interneurons in CA1 and CA3 pyramidal layer subregions. Fig. S2: Hippocampal and entorhinal cortical area selection for 6F3D and PHF1 analyses. Fig. S3: PHF1 co-localization assessments. Fig. S4: Parvalbumin neuronal traces in 12- and 15-month-old NTg and TgF344-AD rats. Fig. S5: No genotype differences in parvalbumin nor somatostatin dendritic length and complexity in 4-month-old NTg and TgF344-AD rats. Fig. S6: NTg and TgF344-AD rats spatial learning in the Barnes maze task. Fig. S7: Confirmation of cognitive resilience in executive function in a separate cohort of 12-month-old TgF344-AD rats. Fig. S8: GABAergic interneurons and parvalbumin dendritic complexity correlate with spatial memory and executive function, respectively, in 15-month-old rats. Table S1: Antibodies and detection kits utilized in this study.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.018 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.886 | 0.164 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".