Additional file 1 of Peroxisome proliferator-activated receptor gamma gene variants modify human airway and systemic responses to indoor dibutyl phthalate exposure
Bibliographic record
Abstract
Additional file 1: Table S1. DNA sequences for PPARG used to perform targeted pyrosequencing. Table S2. The genotypes and GRS are illustrated for rs709158, rs3856806, and rs10865710. Table S3. The weights of each SNP in the construction of P-GRS. Table S4. Oxidative stress-related genes included in the associated OS-GRS and definition of their risk alleles. Table S5. Exposure-by-P-GRS interaction on DBP effects on (A) blood immune cells at 3h, (B) blood immune cells at 20h, and (C) BAL immune cells at 24h. Table S6. Participant characteristics and oxidative stress genetic risk score (OS-GRS). Figure S1. Effect of OS-GRS interaction on DBP effect on IgE and Th2 lymphocytes. Blood allergen-specific IgE at 3 and 20 h (A-B), and BAL allergen-specific IgE at 24 h (C); blood % Th2 lymphocytes at 3 and 20 h (D-E), and BAL % Th2 at 24 h (F) after the allergen challenge post-DBP. The histogram underlying the plot illustrates the distribution of the participants’ OS-GRS. Blood and BAL samples were collected for 16 and 11 participants, respectively. The histogram underlying each plot illustrates the distribution of the participants’ OS-GRS. Effect values represent the DBP-attributable difference between the measurement at the given time point and the baseline. The solid line represents the interaction effect, with the p value corresponding to the interaction significance. The shaded region represents 95% confidence intervals. Figure S2. Exposure-by-OS-GRS interaction on DBP effect on lung function outcomes. Lung function outcomes included: (A) FEV1 (% predicted), ∆20 h; (B) Methacholine challenge (LogPC20), 20 h; (C) FeNO, ∆20 h; (D) Allergen AUC, 3 h. The listed time points refer to the time after the allergen challenge post-DBP or CA exposure. FEV1 = forced expiratory volume in one second; PC20 = concentration leading to 20% fall in FEV1; FeNO = fractional exhaled nitric oxide; AUC = area under curve, measured as percent decline in FEV1 spanning baseline to 3 h after allergen challenge. The histogram underlying each plot illustrates the distribution of the participants’ OS-GRS. Effect values represent the DBP-attributable difference between the measurement at the given time point and the baseline. The solid line represents the interaction effect, with the p value corresponding to the interaction significance. The shaded region represents 95% confidence intervals. Figure S3. PPAR-γ single nucleotide polymorphism rs10865710. Effect modification by genotype G/C or C/C on (A) Blood IgE at 3 and 20 hours post-exposure to CA with allergen challenge (Air+Ag) or DBP with allergen challenge (DBP+Ag), (B) Blood Th2 lymphocytes at 3 and 20 hours post-exposure to CA (Air) or DBP, and (C) BAL Th2 lymphocytes at 24 hours post-exposure to CA (Air) or DBP.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.022 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.863 | 0.102 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".