Additional file 5 of Metabolic switching, growth kinetics and cell yields in the scalable manufacture of stem cell-derived insulin-producing cells
Bibliographic record
Abstract
Additional file 5. Figure S5: Nutrient utilization of kit-derived pancreatic progenitors. (A) Cell density of H1 and H9 derived S4D4 cells (orange dash line= initial seeding density). (B) S4D4 cell yield per input H1 and H9 cell. (C) Flow cytometry quantification of NKX6.1+ and PDX1+ positive cells at S4D4 (n=7 for H1 derivatives-12 biological replicates). (D) Glucose remaining in spent media, (E) percentage glucose consumed and (F) lactate concentration measured in spent media between S1D1 and S4D4. (G) Lactate produced per glucose consumed between S1D1 and S4D4 (D-H: n= 7 biological replicates for H1 and n= 3 biological replicates for H9). For panels D-H, the x-axis labels denote the stage and day, e.g. S1D1= stage 1 day 1. Spent media were sampled 24 ± 2 h from the previous media change
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.020 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.004 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.003 | 0.002 |
| Open science | 0.003 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.854 | 0.228 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".