CD109 Plays a Role in Osteoclastogenesis
Bibliographic record
Abstract
Osteoclasts are large multinucleated cells that arise from the fusion of hematopoietic stem cells from the monocytes-macrophage lineage and play an important role in bone metabolism, specifically in bone resorption. To date, many of the factors involved in Osteoclast fusion remain unclear. The objective of this project was to identify novel factors that regulate Osteoclastogenesis. Methods: microarray, Rt-qPCR and Western blot analysis were performed to identify novel molecules involved in Osteoclastogenesis. A stable CD109 knockdown macrophage cell line was generated using a retroviral shRNA construct. Results: CD109 was identified as a novel molecule that varies its expression during RANKL induced OCG. CD109 KD cell lines showed a deficiency in their osteoclast fusion capacity. Conclusions: pre-osteoclasts express CD109 at different levels while undergoing OCG. CD109 might be an important regulator of OCG although further characterization of its activity is still required.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".