Characterization of a novel downstream target of gata-4 in the heart
Bibliographic record
Abstract
Although cardiac hypertrophy is a compensatory mechanism of the stressed heart, it ultimately leads to cardiac dysfunction. GATA-4, a member of the GATA family, plays an essential role in this process, nevertheless, its mechanism of action is still largely unknown. We have isolated a new evolutionarily conserved protein, ENDO1, that belongs to a new subfamily of PHD finger proteins. In adult mouse, ENDO1 was highly expressed in the kidney, lung, spleen, heart and brain. In ventricular cardiomyocytes, endogenous ENDO1 was expressed in the nucleus and cytoplasm. Overexpression analysis of antisense and sense GATA-4 suggests that GATA-4 downregulates endogenous ENDO1 in cardiomyocytes at the mRNA and protein levels. The protein levels of ENDO1 were enhanced in cardiomyocytes stimulated with phenylephrine, a hypertrophy stimulus. Structure-function analysis revealed that ENDO1 inhibits the activity levels of the BNP promoter. Our results indicate that the ENDO1 protein may play a significant role in cardiac development and differentiation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.009 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".