Comparison of the Osteoinductivity of Infuse® and OP-1® via in vitro and in vivo Assays
Bibliographic record
Abstract
Due to its significant morbidity, alternatives to autogenous bone grafting are required. Recent research has focused on application of growth factors, including bone morphogenetic proteins (BMPs). Two recombinant human BMP (rhBMP) containing bioimplants, Infuse® (rhBMP-2) and OP-1® (rhBMP-7), are approved for human application. Objective: to provide a direct comparison of the two approved rhBMP containing bioimplants in their clinically available forms. Methods: Activity of rhBMP-2 and -7 were tested using the C2C12 cell based assay comparing alkaline phosphatase (ALP) activity. Activity of Infuse® or OP-1® bioimplants containing 52.5µg of rhBMP-2 or rhBMP-7 were compared using a mouse muscle pouch assay and analyzed with micro CT (mCT) and histology. Results: in vitro: rhBMP-2 induced greater ALP production than rhBMP-7 at different time points. In vivo: OP-1® induced greater bone volume than Infuse® of equivalent quality based on mCT. Conclusions: In the clinically available form, OP-1® induced greater bone volume than Infuse®.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".