Cytokine gene expression in CD4+ and CD8+ T cell subsets of chickens infected with Marek's disease virus
Bibliographic record
Abstract
This thesis is an investigation of host responses to Marek's disease virus (MDV) in chickens. In order to study T cell-mediated responses, CD4+ and CD8+ T cells were isolated from spleens of specific pathogen free (SPF) as well as genetically-defined B19 /B19 (susceptible) and B21/B 21 (resistant) chickens at 4, 10, and 21 days post-infection (d.p.i.) with MDV. The expression of cytokine genes, including IFN-[gamma], IL-6, IL-18, IL-4, and IL-10 as well as viral genes, meq and glycoprotein B (gB), was quantified by quantitative real-time reverse transcription-PCR (qRT-PCR). MDV infection elicited an up-regulation in the expression of IL-18 in SPF chickens and IL-10 in genetically-defined chickens in both CD4+ and CD8 + T cell subsets. Despite the elicitation of cytokine responses, a correlation between cytokine gene expression in T cell subsets and genetic resistance versus susceptibility to MD could not be established in this study.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".