Estudio de características genotípicas y fenotípicas entre aislamientos colombianos de cryptococcus gattii serotipo b – patrón vgii, procedentes de Cúcuta y aislamientos responsables de la epidemia en Vancouver, Canadá
Bibliographic record
Abstract
Este estudio recolectó aislamientos colombianos de C. gattii serotipo B, patrón molecular VGII procedentes de Cúcuta, con el objetivo de comparar algunas características genotípicas y fenotípicas para poder determinar diferencias y similitudes existentes con cepas provenientes de la epidemia en Vancouver. Para tal fin, se evaluaron 13 aislamientos clínicos de este mismo serotipo provenientes de Cúcuta mediante técnicas moleculares, logrando concluir que 11 de 13 aislamientos colombianos de C. gattii, presentan un subtipo molecular propio, distinto a los subtipos VGIIa y VGIIb, descritos a partir del brote de Vancouver. Por otra parte, basados en la evaluación de los principales factores de virulencia se escogieron los aislamientos de mayor y menor virulencia, para ser evaluados en un modelo animal, observando en general una menor virulencia en los aislamientos de Colombia, indicando que en Cúcuta no hay aislamientos de C. gattii patrón VGII que representen un riesgo en salud pública. / Abstract : This study collected Colombian strains of C. gattii serotype B, molecular type VGII from Cúcuta, in order to compare some genotypic and phenotypic characteristics to determine differences and similarities with strains from the epidemic in Vancouver. To this end, we evaluated 13 clinical strains of this serotype from Cúcuta using molecular techniques, making the conclusion that 11 of 13 Colombian strains of C. gattii, have a molecular subtype own, different from the subtypes VGIIa and VGIIb described from the Vancouver epidemic. Moreover, based on the assessment of the virulence factors, it was selected strains of higher and lower virulence, being evaluated in an animal model, having a generally less virulent strains in Colombia, stating that in Cúcuta there in not strains of C. gattii VGII that representing a threat to public health.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.004 |
| Meta-epidemiology (narrow) | 0.002 | 0.002 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.004 | 0.003 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".