Factors influencing the murine B and T cell response to human 2-glycoprotein I
Bibliographic record
Abstract
Antiphospholipid syndrome (APS) is defined by the presence of antiphospholipid antibodies (aPL) and clinical manifestations. It is unclear why some patients have high levels of aPL, but no clinical symptoms, while others develop APS. Recent studies have demonstrated T cell reactivity to beta2-glycoprotein I (beta2GPI) in patients with APS. To understand why a T cell response develops selectively in some individuals the requirements for antigen presentation and T cell reactivity were evaluated in a murine model of aPL induction. aPL were readily induced in immunized mice, and required MHC class II, but not CD1, antigen presentation. In contrast, induction of a measurable T cell response to beta2GPI necessitated hyperimmunization in the presence of a polyclonal activator. T cells reacted more to reduced, than native, beta2GPI, suggesting that disulfide bond reduction facilitates antigen processing. These results suggest that a T cell response to beta2GPI occurs only in individuals repeatedly exposed to antigen in a proinflammatory environment.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".