The expression and role of «Tmed2»/TMED2 during the development of the murine embryo and placenta
Bibliographic record
Abstract
Normal development of the placenta is crucial for embryonic survival and growth. Tmed2 is a gene, which has been found to be necessary for the formation of the labyrinth layer of the placenta, as well as for embryonic development. The objectives of this thesis are to: describe the transcripts of Tmed2 using Northern Blot analysis; elucidate the expression pattern of Tmed2 in the developing embryo and placenta using whole mount and section in situ hybridization; determine whether homozygous mutant embryos (Tmed299J/99J) are undergoing ER stress using RT-PCR. Tmed2 has three transcripts; however, only one of these transcripts contains exon 1 of the gene. Tmed2 is expressed during the development of the embryo and placenta in those tissues that are affected in the Tmed299J/99J mutants. Finally, Tmed2 homozygous mutant embryos are not experiencing ER stress. Tmed2 is probably required for the trafficking of an important protein(s) during development.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".