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Record W6981773965

Fabrication of High Solid Silicon Microneedles Based on Anisotropic Etching by Potassium Hydroxide

2023· dissertation· en· W6981773965 on OpenAlexafffund

Bibliographic record

VenueUWSpace (University of Waterloo) · 2023
Typedissertation
Languageen
FieldPharmacology, Toxicology and Pharmaceutics
TopicAdvancements in Transdermal Drug Delivery
Canadian institutionsBlackberry (Canada)
FundersUniversity of Waterloo
KeywordsFabricationEtching (microfabrication)Scanning electron microscopeReactive-ion etchingSiliconPotassium hydroxideAspect ratio (aeronautics)Isotropic etching
DOInot available

Abstract

fetched live from OpenAlex

This thesis presents the research on the high solid silicon microneedles fabrication based on KOH anisotropic etching, aiming at finding a controllable way to fabricate 500 μm high microneedles with good height uniformity and tip sharpness. During this research, 200nm low-stress LPCVD SiNx is used as KOH etching mask; mask shape is square-shaped with its side along <100> direction of silicon wafer; wet etching is done in 29wt% KOH solution at 79oC. 
\nIn the introduction part, a general introduction of modern nanotechnology and microneedles is presented. The nanofabrication techniques that related to microneedles fabrication such as thin film deposition, photolithography, reactive ion etching, and KOH anisotropic etching are introduced for better comprehension of this research. In the experiments part, the fabrication process of microneedles is explained step by step, including SiNx deposition and patterning, KOH wet etching, isotropic reactive ion etching using SF6, and scanning electron microscope characterization. In the discussion part, the geometry of microneedles is studied by SEM characterization. The microneedle shape is determined as an octagonal pyramid, and its sidewall is determined as (311) plane. The aspect ratio of microneedle is 1.414. Then the growth model of microneedles in KOH etching is established. The maximum height of microneedle, obtained right after mask falling off, is positively proportional to its mask size; the real-time height of microneedle has a positive correlation during growth then, after mask falling off, a negative correlation during overetching with time. The height growth rate is 72.5 μm/h, while the height dropping rate during over-etching is 400 μm/h. Finally, an additional step of reactive ion etching by using SF6 gas is introduced following KOH etching before mask falling off to improve the uniformity of microneedles height, which also contributes to improve the tip sharpness. By replacing the inevitable over-etching using KOH with the SF6 RIE step, the standard deviation of microneedles height decreased from 20.50 μm to 11.12 μm; the tip apex diameter decreased from 6.92 μm to 2.71 μm.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.134
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.028
GPT teacher head0.315
Teacher spread0.287 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes2
Has abstractyes

Explore more

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