Investigating the effects of molecular and environmental factors on collagen deposition by cultured rainbow trout (Oncorhynchus mykiss) cardiac fibroblasts
Why this work is in the frame
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Bibliographic record
Abstract
Male rainbow trout undergo sex-specific cardiac remodelling in response to thermal acclimation, which includes changes in collagen composition. To characterize the cellular mechanisms involved we used cardiac fibroblasts from male and female trout to build upon previous studies on the collagen remodelling process. Rainbow trout cardiac fibroblasts were exposed to testosterone, cold acclimation, angiotensin II (ANG II), TGF-, and biomechanical stretch to look at their influences on cell signalling and gene transcription. We hypothesized that fibroblasts would respond to these factors in a pro-collagen response except for testosterone due to its inability to cause change in previous studies with other animals. increase We found that the factors did not act in a consistently pro-fibrotic manner. One notable finding was the induction of cell signalling under cold acclimated stretch. This provides support for the hypothesis that the increased ventricular stretch that occurs under cold acclimation initiates the collagen remodelling response.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it