Investigating the effects of molecular and environmental factors on collagen deposition by cultured rainbow trout (Oncorhynchus mykiss) cardiac fibroblasts
Bibliographic record
Abstract
Male rainbow trout undergo sex-specific cardiac remodelling in response to thermal acclimation, which includes changes in collagen composition. To characterize the cellular mechanisms involved we used cardiac fibroblasts from male and female trout to build upon previous studies on the collagen remodelling process. Rainbow trout cardiac fibroblasts were exposed to testosterone, cold acclimation, angiotensin II (ANG II), TGF-, and biomechanical stretch to look at their influences on cell signalling and gene transcription. We hypothesized that fibroblasts would respond to these factors in a pro-collagen response except for testosterone due to its inability to cause change in previous studies with other animals. increase We found that the factors did not act in a consistently pro-fibrotic manner. One notable finding was the induction of cell signalling under cold acclimated stretch. This provides support for the hypothesis that the increased ventricular stretch that occurs under cold acclimation initiates the collagen remodelling response.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".